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Título: | Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices |
Autor: | Sepúlveda, Borja CSIC ORCID; Sánchez del Río, José CSIC ORCID; Moreno, M. CSIC; Blanco, Francisco J. CSIC ; Mayora, K.; Domínguez Horna, Carlos CSIC ORCID; Lechuga, Laura M. CSIC ORCID | Palabras clave: | Optical biosensors Integrated Mach–Zehnder interferometer Lab-on-a-chip SU-8 microfluidics |
Fecha de publicación: | 2006 | Editor: | Institute of Physics Publishing | Citación: | Journal of Optics - A - Pure and Applied Optics 8(7): S561–S566 (2006) | Resumen: | We present highly sensitive optical biosensors able to be fully integrated in lab-on-a-chip microsystems using standard CMOS compatible processes. These optical biosensors are based on integrated Mach–Zehnder interferometers, which have been designed to have high surface sensitivity and monomode behaviour. As a biosensing application of the devices we show the real-time detection of the covalent immobilization and hybridization of DNA strands without labelling. In order to achieve a lab-on-a-chip portable microsystem, we present the integration of the sensor with a CMOS compatible microfluidic system using SU-8 photolithography patterned layers. | Descripción: | 6 páginas, 8 figuras. | Versión del editor: | http://dx.doi.org/10.1088/1464-4258/8/7/S41 | URI: | http://hdl.handle.net/10261/31337 | DOI: | 10.1088/1464-4258/8/7/S41 | ISSN: | 1464-4258 |
Aparece en las colecciones: | (IMN-CNM) Artículos (IMB-CNM) Artículos |
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