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Closed Access item Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices

Authors:Sepúlveda Martínez, Borja
Sánchez del Río, José
Moreno, M.
Blanco, Francisco
Mayora, K.
Domínguez, Carlos
Lechuga, Laura M.
Keywords:Optical biosensors, Integrated Mach–Zehnder interferometer, Lab-on-a-chip, SU-8 microfluidics
Issue Date:2006
Publisher:Institute of Physics Publishing
Citation:Journal of Optics - A - Pure and Applied Optics 8(7): S561–S566 (2006)
Abstract:We present highly sensitive optical biosensors able to be fully integrated in lab-on-a-chip microsystems using standard CMOS compatible processes. These optical biosensors are based on integrated Mach–Zehnder interferometers, which have been designed to have high surface sensitivity and monomode behaviour. As a biosensing application of the devices we show the real-time detection of the covalent immobilization and hybridization of DNA strands without labelling. In order to achieve a lab-on-a-chip portable microsystem, we present the integration of the sensor with a CMOS compatible microfluidic system using SU-8 photolithography patterned layers.
Description:6 páginas, 8 figuras.
Publisher version (URL):http://dx.doi.org/10.1088/1464-4258/8/7/S41
Appears in Collections:(IMM-CNM) Artículos
(IMB-CNM) Artículos

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