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Title

New downstream regulatory element antagonist modulator gene and polypeptide that is a transcriptional repressor, for identifying antitumor agents

Other TitlesNuevas estrategias de regulación génica mediante la proteina DREAM
AuthorsNaranjo, José Ramón; Mellström, Britt; Dompablo García, Isidro; Alexander Link, Wolfang; Carrión Rodríguez, Ángel Manuel ; Ledo Gómez, Francisco
Issue Date1-Jul-2002
CitationES 2 169 643 A1
Abstract[EN]The DREAM (downstream regulatory element (DRE) antagonist modulator) gene (I) and polypeptide (II), in both native and mutated forms; their use as specific transcriptional silencers of DRE sequences; the use of (II) as a target for identifying new therapeutic compounds and the use as a regulator of CRE-dependent gene expression are new. Independent claims are also included for the following: (1) recombinant vectors containing (I); (2) host cells transformed with the vector of (a); (3) identifying therapeutic agents (A) able to block or activate (II); (4) use of embryonic cells of (2) for creating transgenic animals that have disorders associated with alterations in expression or activity of DREAM; (5) a nucleic acid (III) comprising or containing a 2886 base pair (bp) sequence, representing the complementary sequence to DREAM mRNA; (6) a recombinant vector containing (III); (7) host cells transfected with the vector of (6), with suppressed DREAM expression; and (8) mono- or poly-clonal antibodies (Ab) that recognize (II). [ES]Nuevas estrategias de regulación génica mediante la proteína Dream. La represión de Dream de la expresión génica dependiente de DRE (c-jun y c-fos) es bloqueada por la proteína aCrem. Nuevas formas mutadas de Dream (LVmutDream) escapan del bloqueo de aCrem y permiten definir nuevas estrategias de control terapéutico de procesos patológicos de tipo oncológico, desordenes del aprendizaje, etc. Además, las formas mutadas en las regiones de EF-hands de Dream (EFmutDream) bloquean la actividad de las proteínas Creb y Crem, implicadas en la activación final de multitud de genes dependiente de Cre, y pueden ser utilizadas en la regulación de la expresión de estos genes.
DescriptionFecha de solicitud:01.07.2002.- Titular: Consejo Superior de Investigaciones Científicas (CSIC).
URIhttp://hdl.handle.net/10261/31095
Appears in Collections:(CNB) Patentes
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