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Title: | Dihydroceramide desaturase inhibitors. |
Other Titles: | Inhibidores de la dihidroceramida desaturasa. | Authors: | Fabriàs, Gemma CSIC ORCID ; Llebaria, Amadeu CSIC ORCID; Triola Guillem, Gemma CSIC ORCID | Issue Date: | 27-Jun-2002 | Citation: | WO 02/50018 A1 | Abstract: | [EN]The invention relates to derivatives of cyclopropenylceramide used as desaturase inhibitors characterised by the general formula I, wherein R1 may be an alkyl, alkenyl, alkynyl, aryl or any heterocyclic group, n can have any value whatsoever, be branched or not and contain unsaturations, and R2 and R3 can have the same or different values, represent aryl, heteroaryl, alkyl or acyl groups with one or more unsaturations in the chain, which may be branched or not and substituted by OH groups. The members of this new class of compounds have demonstrated an extraordinary activity as inhibitors of dihydroceramide desaturase and of ceramide biosynthesis and are useful for the treatment of pathologies associated with increases in intracellular ceramide levels. [ES]Derivados de ciclopropenilceramida como inhibidores de desaturasas caracterizados por la fórmula general I, en la que R1 puede ser un grupo alquilo, alquenilo, alquinilo, arilo o cualquier heterociclo, n puede tener cualquier valor y estar ramificada o no y contener insaturaciones y R2 y R3 pueden tener el mismo o distinto valor, representan grupos arilo, heteroarilo, alquilo o acilo con una o varias insaturaciones en la cadena, que puede estar ramificada o no, y sustituida con grupos OH. Miembros de esta nueva clase de compuestos han mostrado una extraordinaria actividad como inhibidores de la dihidroceramida desaturasa y de la biosíntesis de ceramida y son de utilidad para el tratamiento de patologias asociadas a aumentos en los niveles de ceramida intracelular. | Description: | Fecha de solicitud:14.12.2002.- Titular: Consejo Superior de Investigaciones Científicas (CSIC). | URI: | http://hdl.handle.net/10261/31052 |
Appears in Collections: | (IIQ) Patentes |
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