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http://hdl.handle.net/10261/30951
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Asensio, Juan Luis | - |
dc.contributor.author | Hidalgo, Ana | - |
dc.contributor.author | Bastida, Agatha | - |
dc.contributor.author | Torrado, Mario | - |
dc.contributor.author | Corzana, Francisco | - |
dc.contributor.author | Chiara, José Luis | - |
dc.contributor.author | García-Junceda, Eduardo | - |
dc.contributor.author | Cañada, F. Javier | - |
dc.contributor.author | Jiménez-Barbero, Jesús | - |
dc.date.accessioned | 2011-01-05T13:53:05Z | - |
dc.date.available | 2011-01-05T13:53:05Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of the American Chemical Society 127(23): 8278-8279 (2005) | es_ES |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10261/30951 | - |
dc.description | 2 páginas, 3 figuras, 1 esquema.-- Supporting Information Available: Extended experimental details about the design, synthesis, NMR and computational analysis, and enzymatic and biological testing of 5. This material is available free of charge via the Internet at http://pubs.acs.org. | es_ES |
dc.description.abstract | Herein, we describe how the conformational differences exhibited by aminoglycosides in the binding pockets of the ribosome and those enzymes involved in bacterial resistance can be exploited in the design of new antibiotic derivatives with improved activity in resistant strains. The simple modification shown in the figure, leading to the conformationally restricted 5, provides an effective protection against aminoglycoside inactivation by Staphylococcus aureus ANT4, both in vivo and in vitro. | es_ES |
dc.description.sponsorship | We thank DGES (CTQ2004-04494/BQU) and Comunidad de Madrid for funding. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | openAccess | es_ES |
dc.title | A Simple Structural-Based Approach to Prevent Aminoglycoside Inactivation by Bacterial Defense Proteins. Conformational Restriction Provides Effective Protection against Neomycin-B Nucleotidylation by ANT4 | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/ja051722z | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/ja051722z | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
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ja051722z.pdf | 143,46 kB | Adobe PDF | Visualizar/Abrir |
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