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Glycosyl inositol derivatives related to inositolphosphoglycan mediators: Synthesis, structure, and biological activity

AuthorsDietrich, Hansjörg; Espinosa, Juan Félix; Chiara, José Luis ; Jiménez-Barbero, Jesús ; León, Yolanda; Varela-Nieto, Isabel ; Mato, José M.; Cano, Félix H.; Foces-Foces, Concepción ; Martín-Lomas, Manuel
Conformation analysis
Signal transduction
Issue Date1999
CitationChemistry - A European Journal 5(1): 320-336 (1999)
AbstractThe development of effective strategies for the synthesis of phosphatidylinositol precursors such as that which contains the trisaccharide 1, the study of their conformational features and dynamics, and the investigation of their biological properties may result in a better understanding of the mechanism of signal transduction of insulin and a number of growth factors. This new pathway of intracellular signalling has been postulated to proceed through uncharacterized inositolphosphoglycan mediators containing substructures such as 1.
Description17 páginas, 12 figuras, 4 esquemas, 7 tablas.-- Supporting information for this article is available on the WWW under http://www.wiley-vch.de/home/chemistry/ or from the author.
Publisher version (URL)http://dx.doi.org/10.1002/(SICI)1521-3765(19990104)5:1<320::AID-CHEM320>3.0.CO;2-K
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