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Title

Glycosides of N-Acetyl-6-0-[2,2 bis (hydroxymethyl)-3- hydroxypropyl]-d-glucosamine, method for the obtention thereof and their uses in the treatment of brain tumors.

Other TitlesGlicosidos de N- Acetil-6-0-[2,2, bis-(hidroximetil)-3- hidroxipopil]-d-glucosamina, procedimiento de obtención y uso en el tratamiento de tumores cerebrales.
AuthorsBernabé, Manuel ; Fernández-Mayoralas, Alfonso ; Nieto-Sampedro, Manuel ; Vaquero, Jesús; Zurita Castillo, Mercedes
Issue Date25-Oct-2001
CitationWO 01/79243 A1
Abstract[EN]The invention describes a method for obtaining glycosides from monosaccharide N-acetyl-D-glucosamine derivatives and a research on its glioblastoma inhibiting and cytotoxic activity. Glycosides of general formula (I) have been prepared from monosaccharide N-acetyl-D-glucosamine, wherein aglycone R<1> is a hydrophobic radical, preferably a linear or branched hydrocarbonated 8-16 carbon chain. The invention also relates to the use of glycosides of N-acetyl-6-O-[2,2-bis(hydroxymethyl)-3-hydroxypropyl]-D-glucosamine for inhibiting human glioma cultures. [ES]En esta patente se describe un procedimiento de obtención de glicósidos derivados del monosacárido N-acetil-D-glucosamina y la investigación sobre su actividad inhibitoria y citóxica de gliobastomas. Se han preparado glicósidos de fórmula general 1 a partir del monosacárido N-acetil-D-glucosamina, donde el aglicón R<1> es un resto de naturaleza hidrofóbica,preferentemente una cadenahodrocarbonada de 8-16 carbonos, lineal o ramificada. Uso de los glicósidos de N-acetil-6-0-[21,2 bis(hidroximetil)-3-hidroxipropil]-D-glucosamina para inhibición de la proliferación de glicomas humanos en cultivo.
DescriptionFecha de solicitud:06.04.2001.- Titulares: Consejo Superior de Investigaciones Científicas (CSIC).- Hospital Universitario Clínica Puerta de Hierro.
URIhttp://hdl.handle.net/10261/29924
Appears in Collections:(IC) Patentes
(IQOG) Patentes
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