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Title

Structure of swine vesicular disease virus: mapping of changes occurring during adaptation of human coxsackie B5 virus to infect swine

AuthorsVerdaguer, Núria ; Jiménez Clavero, Miguel A.; Fita, Ignacio ; Ley, Victoria
Issue DateSep-2003
PublisherAmerican Society for Microbiology
CitationJournal of Virology 77(18): 9780-9789 (2003)
AbstractThe structure of swine vesicular disease virus (SVDV) was solved and refined at a 3.0-A resolution by X-ray crystallography to gain information about the role of sequence changes that occurred as this virus evolved from the parental human pathogen coxsackievirus B5 (CVB5). These amino acid substitutions can be clustered in five distinct regions: (i) the antigenic sites, (ii) the hydrophobic pocket of the VP1 beta-sandwich, (iii) the putative CAR binding site, (iv) the putative heparan sulfate binding site, and (v) the fivefold axis. The VP1 pocket is occupied by a branched pocket factor, apparently different from that present in the closely related virus CVB3 and in other picornaviruses. This finding may be relevant for the design of new antiviral compounds against this site. Density consistent with the presence of ions was observed on the fivefold and threefold axes. The structure also provided an accurate description of the putative receptor binding sites.
Description10 pages, 4 figures, 2 tables.-- PMID: 12941886 [PubMed].-- PMCID: PMC224589.
Publisher version (URL)http://dx.doi.org/10.1128/JVI.77.18.9780-9789.2003
URIhttp://hdl.handle.net/10261/29091
DOI10.1128/JVI.77.18.9780-9789.2003
ISSN0022-538X
E-ISSN1098-5514
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