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Title

Citrulinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis

AuthorsHaro Villar, Isabel; Gómara Elena, María José; Sanmartí, Raimon; Pérez Rodríguez, María Luisa
Issue Date10-Mar-2010
CitationEP2161284 A1
AbstractThe present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the +- or chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease.
Las preocupaciones de la presente invención un polipéptido quimérico, capaz de detectar los anticuerpos generados en la artritis reumatoide, comprendiendo por lo menos dos citrulinated subunidades del péptido: (i) uno derivó de + - o la cadena de la fibrina y (ii) al segundo derivó del filaggrin. Además, la invención comprende una composición antigénica, un método y un estuche para el diagnóstico de la artritis reumatoide, de la detección de los autoanticuerpos generados durante el curso de la enfermedad dicha.
URIhttp://hdl.handle.net/10261/28243
Appears in Collections:(IQAC) Patentes
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