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Inhibitors of enzyme 06-alkylguanine-DNA-methyltransferase for cancer treatment

Other TitlesInhibidores de la enzima 06-alquilguanina-ADN-metil-transferasa para el tratamiento del cáncer
AuthorsRamírez Ortiz, Miguel Ángel; Morreale, Antonio ; Gil Redondo, Rubén ; Ruiz, Federico M. ; Fábrega Clavería, Carme; Bravo, Jerónimo
Issue Date10-Dec-2009
CitationES 2330495 (A1)
AbstractThe invention relates to the use of compounds derived from piperadinyl-methyl-tetrazole-quinolinone and derived from diphenyl-triazolo- pyrimidine as inhibitors of the reparative action of the DNA produced by enzyme O6-alkylguanine-DNA-methyltransferase, and to pharmaceutical compositions containing same, for the preparation of coadjuvant drugs for use in antitumour therapy using alkylating agents.
La invención relaciona a la utilización de compuestos derivada de piperadinyl-metil-tetrazol-quinolinona y derivada de pirimidina del difenilo-triazolo como inhibidores de la acción reparativa de la DNA producida por la enzima O6-alkylguanine-DNA-methyltransferase, y a contener de las composiciones farmacéuticas mismo, para la preparación de los fármacos coadjuvant para el uso en terapia antitumour usando a agentes de alquilación.
DescriptionFecha de solicitud: 10-12-2009.- Titular: Consejo Superior de Investigaciones Científicas (CSIC)
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(IBV) Patentes
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