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Open Access item Scalable fabrication of immunosensors based on carbon nanotube polymer composites

Authors:Mendoza Gómez, Ernest
Orozco, Jahir
Jiménez-Jorquera, Cecilia
González-Guerrero, Ana Belén
Calle Martín, Ana
Lechuga, Laura M.
Fernández Sánchez, César
Issue Date:29-Jan-2008
Publisher:American Institute of Physics
Citation:Applied Physics Letters 19(7): 075102 (2008)
Abstract:In this work we present the fabrication and characterization of immunosensors based on polystyrene (PS)–multiwalled carbon nanotube (MWCNT) composites. The electrochemical properties of the sensors have been investigated and show that the surface area is increased upon addition of the MWCNT–PS layer. Furthermore, a plasma activation process is used to partially remove the PS and expose the MWCNTs. This results in a huge increase in the electrochemical area and opens up the possibility of binding biomolecules to the MWCNT wall. The MWCNTs have been functionalized covalently with a model antibody (rabbit IgG). The biosensors have been tested using amperometric techniques and show detection limits comparable to standard techniques such as ELISA.
Description:7 páginas, 4 figuras.
Publisher version (URL):http://dx.doi.org/10.1088/0957-4484/19/7/075102
URI:http://hdl.handle.net/10261/27984
ISSN:0003-6951
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