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Improvements in or relating to compositions for the treatment or prophylaxis of viral infections

AuthorsBalzarini, Jan; Camarasa Rius, María José ; Velázquez, Sonsoles
Issue Date12-Mar-2009
CitationWO 2009030410 (A1)
AbstractA compound of the general formula (III): wherein X is O, S, NH or CH2; Y is O, S or NH; Z is O, S or CH2; R1 is C1-8 alkyl, especially C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl; at least one of R2 and R3 is H-[R4-R5]n-R6-, in which: H-[R4-R5]n- comprises an oligopeptide, R4 being an amino acid and R5 being an amino acid selected from proline, alanine, hydroxyproline, dihydroxyproline, thiazolidinecarboxylic acid (thioproline), dehydroproline, pipecolic acid (L-homoproline), azetidinecarboxylic acid, aziridinecarboxylic acid, glycine, serine, valine, leucine, isoleucine and threonine, R6 is a neutral, non-polar amino acid moiety that is bonded to R5 by a peptide bond, and n is 1, 2, 3, 4 or 5; and the other of R3 and R2 is H-[R4-R5]n-R6- or H; or a pharmaceutically acceptable salt thereof.
Un compuesto de la fórmula general (iii): en donde X es O, S, NH o CH2 Y es O, S o NH Z es O, S o CH2 R1 es C1-8 el alquílico, especialmente alquílico C1-6, preferiblemente n-alquílico, e.g., n-pentil o n-hexyl por lo menos uno de R2 y de R3 es el h [R4-R5] n-R6-, en el cual: El h [R4-R5] n comprende un oligopéptido, un ser R4 un aminoácido y un ser R5 un aminoácido seleccionado de la prolina, de la alanina, de la hidroxiprolina, del dihydroxyproline, del ácido thiazolidinecarboxylic (tioprolina), del dehydroproline, del ácido pipecolic (L-homoproline), del ácido azetidinecarboxylic, del ácido aziridinecarboxylic, de la glicina, de la serina, de la valina, de la leucina, de la isoleucina y de la treonina, R6 es los restos neutros, no polares del aminoácido que son unidos a R5 por un enlace peptídico, y n es 1, 2, 3, 4 o 5 y el distinto de R3 y de R2 es h [R4-R5] n-R6- o H o una sal farmacéuticamente aceptable de eso.
DescriptionFecha de solicitud: 12-03-2009.- Titular: Consejo Superior de Investigaciones Científicas (CSIC)
Appears in Collections:(IQM) Patentes
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