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Open Access item Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits

Authors:Pérez, S.
Solans, Conxita
Bregante, M. A.
Pinilla, I.
García, M. A.
Honrubia, A.
Issue Date:Oct-2002
Publisher:Oxford University Press
Citation:Journal of Antimicrobial Chemotherapy 50(4): 541-545 (2002)
Abstract:The pharmacokinetics of grepafloxacin were determined in albino and pigmented rabbits following a single 10 mg/kg intravenous administration. The penetration of grepafloxacin into various ocular tissues was also determined after continuous intravenous infusion in both types of animal. Grepafloxacin showed a icompartmental model of distribution in both pigmented and albino rabbits with significant differences in the pharmacokinetics between the two types of animal. After continuous intravenous infusion, significantly greater penetration of grepafloxacin was found in the iris, cornea and chorioretina of pigmented rabbits compared with albino rabbits.
Description:6 pages, 2 figures, 2 tables.-- PMID: 12356799 [PubMed].
Publisher version (URL):http://dx.doi.org/10.1093/jac/dkf178
ISSN:0305-7453 (Print)
1460-2091 (Online)
Appears in Collections:(IQAC) Artículos

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