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Título : Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits
Autor : Pérez, S.; Solans, Conxita; Bregante, M. A.; Pinilla, I.; García, M. A.; Honrubia, A.
Fecha de publicación : oct-2002
Editor: Oxford University Press
Citación : Journal of Antimicrobial Chemotherapy 50(4): 541-545 (2002)
Resumen: The pharmacokinetics of grepafloxacin were determined in albino and pigmented rabbits following a single 10 mg/kg intravenous administration. The penetration of grepafloxacin into various ocular tissues was also determined after continuous intravenous infusion in both types of animal. Grepafloxacin showed a icompartmental model of distribution in both pigmented and albino rabbits with significant differences in the pharmacokinetics between the two types of animal. After continuous intravenous infusion, significantly greater penetration of grepafloxacin was found in the iris, cornea and chorioretina of pigmented rabbits compared with albino rabbits.
Descripción : 6 pages, 2 figures, 2 tables.-- PMID: 12356799 [PubMed].
Versión del editor: http://dx.doi.org/10.1093/jac/dkf178
URI : http://hdl.handle.net/10261/27356
DOI: 10.1093/jac/dkf178
ISSN: 0305-7453 (Print)
1460-2091 (Online)
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