Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/27353
Title: Direct inhibition of (Z)-9 desaturation of (E)-11-tetradecenoic acid by methylenehexadecenoic acids in the biosynthesis of Spodoptera littoralis sex pheromone
Authors: Fabriàs, Gemma, Gosalbo, Laura, Quintana, Jordi, Camps Díez, Francisco
Keywords: Inhibition
Desaturase
Sex pheromone
Cyclopropene fatty acid
Biosynthesis
Spodoptera littoralis
Lepidoptera
Insect
Issue Date: Jul-1996
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: Analysis by gas chromatography coupled to mass spectrometry demonstrated that 11,12-methylenehexadec-11-enoic acid and 12,13-methylenehexadec-12-enoic acid are beta-oxidized in Spodoptera littoralis sex pheromone gland to 9, 10-methylenetetradec-10-enoic acid and 10,11-methylenetetradec-10-enoic acid, respectively. This result supported our previous hypothesis that inhibition of the (Z)-9 desaturation of (E)-11-tetradecenoic acid by those C-16 fatty acids is actually caused by their corresponding beta-oxidation products. However, although (2,2,3,3-2H4)-11,12-methylenehexadec-11-enoic acid was not chain-shortened to the C-14 derivative, its activity as inhibitor of the (Z)-9 desaturation reaction was similar to that exhibited by 11,12-methylenehexadec-11-enoic acid. Therefore, the C-16 cyclopropene fatty acids may inhibit the (Z)-9 desaturation enzyme by themselves, probably through interaction of the cyclopropene ring with a binding site of the enzyme with the substrate double bond.
Description: 7 pages, 7 figures. PMID: 8827522 [PubMed].
Publisher version (URL): http://www.jlr.org/cgi/reprint/37/7/1503
URI: http://hdl.handle.net/10261/27353
ISSN: 0022-2275 (Print)
Citation: Journal of Lipid Research 37(7): 1503-1509 (1996)
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