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Título: | Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers |
Autor: | Ferreira, Rubén CSIC ORCID; Aviñó, Anna CSIC ORCID; Pérez-Tomás, Ricardo; Gargallo, Raimundo; Eritja Casadellà, Ramón CSIC ORCID | Fecha de publicación: | 2010 | Editor: | Sage Publications | Citación: | Journal of Nucleic Acids 2010 (2010) | Resumen: | The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis, which showed a clear affinity for DNA sequences that form G-quadruplexes and parallel triplexes. The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. These spectral changes were used to calculate the binding constants (K). Log K were found to be in the order of 4–6. | Descripción: | 10 pages, 4 figures, 2 tables. | Versión del editor: | http://dx.doi.org/10.4061/2010/489060 | URI: | http://hdl.handle.net/10261/26815 | DOI: | 10.4061/2010/489060 | ISSN: | 2090-021X (Online) |
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