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Open Access item The SV40 T antigen modulates CBP histone acetyltransferase activity

Authors:Aragón Valls, Esther
Cruz, Xavier de la
Martínez-Balbás, Marian
Issue Date:15-Jun-2003
Publisher:Oxford University Press
Citation:Nucleic Acids Research 31(12): 3114–3122 (2003)
Abstract:Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacetylases by trichostatin A increases the SV40 infectivity rate. These findings highlight the importance of histone acetylation in the regulation of the cell cycle by oncoviral proteins.
Description:9 pages, 6 figures, 1 table.-- PMID: 12799439 [PubMed].-- PMCID: PMC162251.
Publisher version (URL):http://dx.doi.org/10.1093/nar/gkg418
ISSN:0305-1048 (Print)
1362-4962 (Online)
Appears in Collections:(IQAC) Artículos

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