English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/25299
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Physiology and pharmacology of the vanilloid receptor

AuthorsMesseguer Peypoch, Ángel ; Planells-Cases, Rosa; Ferrer-Montiel, Antonio
KeywordsVanilloid receptor
Analgesic drugs
Physiological activity
Issue DateJan-2006
PublisherBentham Science Publishers
CitationCurrent Neuropharmacology 4(1): 1-15 (2006)
AbstractThe identification and cloning of the vanilloid receptor 1 (TRPV1) represented a significant step for the understanding of the molecular mechanisms underlying the transduction of noxious chemical and thermal stimuli by peripheral nociceptors. TRPV1 is a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. TRPV1 channel activity is remarkably potentiated by pro-inflammatory agents, a phenomenon that is thought to underlie the peripheral sensitisation of nociceptors that leads to thermal hyperalgesia. Cumulative evidence is building a strong case for the involvement of this receptor in the etiology of both peripheral and visceral inflammatory pain, such as inflammatory bowel disease, bladder inflammation and cancer pain. The validation of TRPV1 receptor as a key therapeutic target for pain management has thrust intensive drug discovery programs aimed at developing orally active antagonists of the receptor protein. Nonetheless, the real challenge of these drug discovery platforms is to develop antagonists that preserve the physiological activity of TRPV1 receptors while correcting over-active channels. This is a condition to ensure normal pro-prioceptive and nociceptive responses that represent a safety mechanism to prevent tissue injury. Recent and exciting advances in the function, dysfunction and modulation of this receptor will be the focus of this review.
Description15 pages, 7 figures.-- PMID: 18615132 [PubMed].-- PMCID: PMC2430674.
Publisher version (URL)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430674
URIhttp://hdl.handle.net/10261/25299
ISSN1570-159X
E-ISSN1875-6190
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
Messeguer_Angel_et_al.pdf3,13 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.