Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/25265
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Alonso Guerrero, Astrid | - |
dc.contributor.author | Martínez-Alonso, Carlos | - |
dc.contributor.author | Van Wely, Karel H. M. | - |
dc.date.accessioned | 2010-06-14T12:27:27Z | - |
dc.date.available | 2010-06-14T12:27:27Z | - |
dc.date.issued | 2010-05-17 | - |
dc.identifier.govdoc | http://www.celldiv.com/content/5/1/13 | - |
dc.identifier.issn | 1747-1028 | - |
dc.identifier.uri | http://hdl.handle.net/10261/25265 | - |
dc.description.abstract | Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis. The recent report of spindle-induced DNA damage provides evidence for a single mechanism responsible for the most prominent genetic defects in chromosomal instability. Spindle-induced DNA damage is brought about by uncorrected merotelic attachments, which cause kinetochore distortion, chromosome breakage at the centromere, and possible activation of DNA damage repair pathways. Although merotelic attachments are common early in mitosis, some escape detection by the kinetochore pathway. As a consequence, a proportion of merotelic attachments gives rise to chromosome breakage in normal cells and in carcinomas. An intrinsic chromosome segregation defect might thus form the basis of tumor initiation. We propose a hypothesis in which merotelic attachments and chromosome breakage establish a feedback loop that results in relaxation of the spindle checkpoint and suppression of anti-proliferative pathways, thereby promoting carcinogenesis. | en_US |
dc.description.sponsorship | The publication costs for this manuscript were financed by grant PS09/00572 (Fondo de Investigación en Salud) and the experimental work by grant S-BIO-0189-2006 (Comunidad Autonoma de Madrid). The Department of Immunology and Oncology was founded and is supported by the Spanish National Research Council (CSIC) and by Pfizer. | en_US |
dc.format.extent | 1279147 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.ispartofseries | Cell Division | en_US |
dc.relation.ispartofseries | 5:13 | en_US |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | en_US |
dc.subject | Chromosomal instability | en_US |
dc.subject | mitosis | en_US |
dc.title | Merotelic attachments and non-homologous end joining are the basis of chromosomal instability | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1186/1747-1028-5-13 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1186/1747-1028-5-13 | en_US |
dc.identifier.pmid | 20478024 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (CNB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1747-1028-5-13.pdf | 1,25 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 08-abr-2024
SCOPUSTM
Citations
21
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 27-feb-2024
Page view(s)
359
checked on 23-abr-2024
Download(s)
247
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.