Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/25055COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion |
Autor: | Calés, Carmela CSIC ORCID; Román-Trufero, Mónica CSIC; Pavón, Leticia; Serrano, Iván CSIC; Melgar, Teresa CSIC | Fecha de publicación: | feb-2008 | Editor: | American Society for Microbiology | Citación: | Molecular and Cellular Biology 28(3): 1018-1028 (2008) | Resumen: | Polycomb group (PcG) proteins act as positive regulators of cell proliferation. Ring1B is a PcG gene essential for embryonic development, but its contribution to cell turnover in regenerating tissues in not known. Here, we have generated a conditional mouse mutant line to study the Ring1B role in adult hematopoiesis. Mutant mice developed a hypocellular bone marrow that paradoxically contained an enlarged, hyperproliferating compartment of immature cells, with an intact differentiation potential. These alterations were associated with differential upregulation of cyclin D2, which occurred in all mutant bone marrow cells, and of p16(Ink4a), observed only in the differentiated compartment. Concurrent inactivation of Ink4a rescued the defective proliferation of maturing cells but did not affect the hyperproliferative activity of progenitors and resulted in a shortening of the onset of lymphomas induced by Ink4a inactivation. These data show that Ring1B restricts the progenitors' proliferation and promotes the proliferation of their maturing progeny by selectively altering the expression pattern of cell cycle regulators along hematopoietic differentiation. The novel antiproliferative role of Ring1B's downregulation of a cell cycle activator may play an important role in the tight control of hematopoietic cell turnover. | Descripción: | 11 pages, 7 figures.-- et al. | Versión del editor: | http://dx.doi.org/10.1128/MCB.01136-07 | URI: | http://hdl.handle.net/10261/25055 | DOI: | 10.1128/MCB.01136-07 | ISSN: | 0270-7306 |
| Aparece en las colecciones: | (CIB) Artículos (IIBM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Calés -et-el-MCB_2008.pdf | 482,89 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
40
checked on 01-abr-2024
SCOPUSTM
Citations
77
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
77
checked on 27-feb-2024
Page view(s)
379
checked on 18-abr-2024
Download(s)
299
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.