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Title

Surveillance of antibiotic resistance evolution and detection of class 1 and 2 integrons in human isolates of multi-resistant Salmonella Typhimurium obtained in Uruguay between 1976 and 2000.

AuthorsMacedo-Viñas, Marina; Cordeiro, Nicolás F.; Bado, Inés; Herrera-León, Silvia; Vola, Magdalena; Robino, Luciana; González-Sanz, Rubén; Mateos, Soledad; Schelotto, Felipe; Algorta, Gabriela; Ayala, Juan Alfonso ; Echeita, Aurora; Vignoli, Rafael
KeywordsSalmonella
Antibiotics
Resistance
Integrons
Evolution
Issue Date13-May-2009
PublisherElsevier
CitationInt J Infect Dis.13(3):342-8 (2009)
Abstract[Objectives] To study the evolution of antibiotic resistance in isolates of Salmonella enterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) obtained in Uruguay between the years 1976 and 2000, and to determine the incidence of class 1 and 2 integrons in the multiresistant isolates.
[Methods] We studied 258 strains of Salmonella Typhimurium from various sources, isolated between 1976 and 2000. We determined the evolution of antibiotic resistance and the distribution of class 1 and 2 integrons in all isolates by means of disk diffusion assays and PCR.
[Results] During the period 1989—2000 resistance to streptomycin was 56.8%, tetracycline 13.6%, sulfonamides 11.2%, and ampicillin 7.2%. Resistance to gentamicin, kanamycin, chloramphenicol, and nalidixic acid were lower than 5%; no resistance was detected to fluoroquinolones, oxyiminocephalosporins, and amikacin. These results show a dramatic decrease with respect to values found in the period 1976—1988. In this period, resistance to streptomycin was 63.2%, tetracycline 36.8%, sulfonamides 32.3%, and ampicillin 27.8%. Throughout the two periods, 29 multi-resistant
Publisher version (URL)http://dx.doi.org/10.1016/j.ijid.2008.07.012
URIhttp://hdl.handle.net/10261/24891
DOI10.1016/j.ijid.2008.07.012
ISSN1201-9712
Appears in Collections:(CBM) Artículos
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