Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24867
Título : Vacuole membrane protein 1, autophagy and much more
Autor : Calvo-Garrido, Javier, Carilla-Latorre, Sergio, Escalante, Ricardo
Palabras clave : Vacuole membrane protein 1
Organelle biogenesis
Autophagy
Protein secretion
Osmoregulation
Dictyostelium
Endoplasmic reticulum
Fecha de publicación : Aug-2008
Editor: Landes Bioscience
Citación : Autophagy 16(4): 835-837 (2008)
Resumen: Vacuole membrane protein 1 (Vmp1) is a putative transmembrane protein that has been associated with different functions including autophagy, cell adhesion, and membrane traffic. Highly similar proteins are present in lower eukaryotes and plants although a homologue is absent in the fungi lineage. We have recently described the first loss-of-function mutation for a Vmp1 homologue in a model system, Dictyostelium discoideum. Our results give a more comprehensive view of the intricate roles played by this new gene. Dictyostelium Vmp1 is an endoplasmic reticulum-resident protein. Cells deficient in Vmp1 display pleiotropic defects in the context of the secretory pathway such as organelle biogenesis, the endocytic pathway, and protein secretion. The biogenesis of the contractile vacuole, an organelle necessary to survive under hypoosmotic conditions, is compromised as well as the structure of the endoplasmic reticulum and the Golgi apparatus. Transmission electron microscopy also shows abnormal accumulation of aberrant double-membrane vesicles, suggesting a defect in autophagosome biogenesis or maturation. The expression of a mammalian Vmp1 in the Dictyostelium mutant complements the phenotype suggesting a functional conservation during evolution. We are taking the first steps in understanding the function of this fascinating protein and recent studies have brought us more questions than answers about its basic function and its role in human pathology.
Descripción : 3 pages, 2 figures, 1 table.-- Article addendum.-- This article is Open Access.
Versión del editor: http://www.landesbioscience.com/journals/autophagy/article/6574
URI : http://hdl.handle.net/10261/24867
ISSN: 1554-8627
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