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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/24781
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dc.contributor.authorMartín-Duque, Pilar-
dc.contributor.authorQuintanilla, Miguel-
dc.contributor.authorMcNeish, Iain-
dc.contributor.authorLopes, Rita-
dc.contributor.authorRomero, Jesús-
dc.contributor.authorRomero, Diana-
dc.contributor.authorRamón y Cajal, Santiago-
dc.contributor.authorVassaux, Georges-
dc.date.accessioned2010-05-27T11:18:49Z-
dc.date.available2010-05-27T11:18:49Z-
dc.date.issued2006-05-
dc.identifier.citationInternational Journal of Molecular Medicine 17(5): 841-847 (2006)en_US
dc.identifier.issn1107-3756-
dc.identifier.urihttp://hdl.handle.net/10261/24781-
dc.description7 pages, 6 figures.-- et al.en_US
dc.description.abstractThe cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. This observation raises the possibility that factors affecting caspase activation might be important determinants of anticancer drug sensitivity. Ectopic expression of caspase-1 has been shown to trigger apoptosis. However, the role of caspase-1 in apoptosis is now considered as minor compared to other caspases. In patients, high levels of caspase-1 expression may be associated with spontaneous regression in neuroblastomas and with a good clinical response to chemotherapy in acute myeloid leukemia and osteosarcoma. In experimental therapeutics for cancer, caspase-1 has been related to some anticancer activity. These observations led us to examine the effect of over-expression on the response to chemotherapy and radiotherapy in vitro and in vivo. Caspase-1 expression mediated by an adenoviral vector was able to kill directly cells and to sensitise the remaining cells to cisplatin or γ-radiation in vitro. In HeLa cells stably transfected with caspase-1, sensitisation to cisplatin was due to an amplification of the cisplatin-induced mitochondrial apoptotic pathway activation. Caspase-1 mediated sensitisation to cisplatin and γ-radiation was also observed in vivo. Altogether, we conclude that caspase-1 can act as a radio- and chemo-sensitiser, in vitro and in vivo.en_US
dc.description.sponsorshipResearch in the laboratory of Georges Vassaux is supported Cancer Researh-UK, Royal Society-CSIC and Pilar Martínez Duque by Programa Ramón y Cajal del Ministerio de Educación y Ciencia Español and Universidad Francisco de Vitoria.en_US
dc.format.extent172921 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherSpandidos Publicationsen_US
dc.rightsopenAccessen_US
dc.subjectCaspasesen_US
dc.subjectSensitisationen_US
dc.subjectChemotherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectGene therapyen_US
dc.titleCaspase-1 as a radio- and chemo-sensitiser in vitro and in vivoen_US
dc.typeartículoen_US
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://www.spandidos-publications.com/ijmm/article.jsp?article_id=ijmm_17_5_841en_US
dc.identifier.pmid16596269-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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