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Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents

AuthorsPérez-Mayoral, Elena; Soler-Padrós, Jordi; Negri, Viviana ; Cerdán, Sebastián ; Ballesteros, Paloma
KeywordsLanthanide complexes
Contrast agents
Heterocyclic ligands
MR imaging
Issue Date9-Aug-2007
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 12(8): 1771-1795 (2007)
AbstractMagnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings.
Description25 pages, 7 figures, 25 schemes.
Publisher version (URL)http://dx.doi.org/10.3390/12081771
Appears in Collections:(IIBM) Artículos
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