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Open Access item Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents

Authors:Pérez-Mayoral, Elena
Soler-Padrós, Jordi
Negri, Viviana
Cerdán, Sebastián
Ballesteros, Paloma
Keywords:Lanthanide complexes, Contrast agents, Heterocyclic ligands, MR imaging
Issue Date:9-Aug-2007
Publisher:Molecular Diversity Preservation International
Citation:Molecules 12(8): 1771-1795 (2007)
Abstract:Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings.
Description:25 pages, 7 figures, 25 schemes.
Publisher version (URL):http://dx.doi.org/10.3390/12081771
URI:http://hdl.handle.net/10261/24730
ISSN:1420-3049
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Appears in Collections:(IIBM) Artículos

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