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Título : Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes
Autor : Figueroa, Angélica, Cuadrado, Ana, Gorospe, Myriam, Muñoz Terol, Alberto
Fecha de publicación : Jul-2003
Editor: American Society for Microbiology
Citación : Molecular and Cellular Biology 23(14): 4991-5004 (2003)
Resumen: In this report, we investigate the role of the RNA-binding protein HuR during skeletal myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in regenerating mouse muscle, HuR cytoplasmic abundance increased dramatically, returning to a predominantly nuclear presence upon completion of myogenesis. mRNAs encoding key regulators of myogenesis-specific transcription (myogenin and MyoD) and cell cycle withdrawal (p21), bearing AU-rich regions, were found to be targets of HuR in a differentiation-dependent manner. Accordingly, mRNA half-lives were highest during differentiation, declining when differentiation was completed. Importantly, HuR-overexpressing C2C12 cells displayed increased target mRNA expression and half-life and underwent precocious differentiation. Our findings underscore a critical function for HuR during skeletal myogenesis linked to HuR's coordinate regulation of muscle differentiation genes.
Descripción : 14 pages, 7 figures.-- et al.
Versión del editor:
ISSN: 0270-7306
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