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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/24570
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dc.contributor.authorPeinado, Héctor-
dc.contributor.authorMarín, Faustino-
dc.contributor.authorCubillo, Eva-
dc.contributor.authorNieto, M. Ángela-
dc.contributor.authorCano, Amparo-
dc.date.accessioned2010-05-21T09:38:36Z-
dc.date.available2010-05-21T09:38:36Z-
dc.date.issued2004-06-01-
dc.identifier.citationJournal of Cell Science 117(13): 2827-2839 (2004)en_US
dc.identifier.issn0021-9533-
dc.identifier.urihttp://hdl.handle.net/10261/24570-
dc.description13 páginas, 7 figuras.-- et al.en_US
dc.description.abstractThe transcription factors Snail and E47 are direct repressors of E-cadherin, with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed in the prototypic epithelial MDCK cell line. The role of these repressors in the invasive process and in other tumorigenic properties is, nevertheless, still poorly understood. However, organotypic cultures and in vivo transplantation assays indicate that cells expressing MDCK-Snail and MDCK-E47 exhibit significant differences. MDCK-Snail cells have a higher infiltrative potential than MDCK-E47 cells. Interestingly, both cell types induce angiogenesis of the host stromal tissue in transplantation assays, but this property is greatly enhanced in transplants of MDCK-E47 cells. Xenografted tumours induced in nude mice also show signs of strong angiogenic potential, again markedly increased in tumours induced by MDCK-E47 which exhibit a higher vessel density and proliferation rate than those induced by MDCK-Snail cells. These results suggest differential roles for Snail and E47 E-cadherin repressors in tumour progression where Snail is implicated in promoting the initial invasion and E47 plays an active role in tumour cell growth by promoting angiogenesis.en_US
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Science and Technology (SAF2001-2819); Instituto de Salud Carlos III (FIS01/1174; FIS03C03/10) and by Justesa Imagen S.A. H.P. and E.C. are supported by predoctoral fellowships from the Spanish Ministry of Education, Culture and Sports and Instituto de Salud Carlos III, respectively. F.M. is supported by a contract from the Spanish Ministry of Science and Technology.en_US
dc.format.extent1120336 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherCompany of Biologistsen_US
dc.rightsopenAccessen_US
dc.subjectSnailen_US
dc.subjectE47en_US
dc.subjectE-cadherinen_US
dc.subjectInvasionen_US
dc.subjectAngiogenesisen_US
dc.subjectTransplantation assaysen_US
dc.titleSnail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivoen_US
dc.typeartículoen_US
dc.identifier.doi10.1242/jcs.01145-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1242/jcs.01145en_US
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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