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Cyclic AMP can decrease expression of genes subject to catabolite repression in Saccharomyces cerevisiae

AuthorsZaragoza, Oscar; Lindley, Chris; Gancedo, Juana M.
Issue DateApr-1999
PublisherAmerican Society for Microbiology
CitationJournal of Virology 181(8): 2640-2642 (1999)
AbstractExternal cyclic AMP (cAMP) hindered the derepression of gluconeogenic enzymes in a pde2 mutant ofSaccharomyces cerevisiae, but it did not prevent invertase derepression. cAMP reduced nearly 20-fold the transcription driven by upstream activation sequence (UAS1FBP1) from FBP1, encoding fructose-1,6-bisphosphatase; it decreased 2-fold the activation of transcription by UAS2FBP1. Nuclear extracts from cells derepressed in the presence of cAMP were impaired in the formation of specific UASFBP1-protein complexes in band shift experiments. cAMP does not appear to act through the repressing protein Mig1. Control of FBP1 transcription through cAMP is redundant with other regulatory mechanisms.
Description3 pages, 2 figures, 2 table.
Publisher version (URL)http://jb.asm.org/cgi/content/short/181/8/2640
Appears in Collections:(IIBM) Artículos
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