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dc.contributor.authorCastillo Expósito, José A.-
dc.date.accessioned2010-05-03T08:41:11Z-
dc.date.available2010-05-03T08:41:11Z-
dc.date.issued2007-
dc.identifier.isbn978-84-690-4710-1-
dc.identifier.otherB-14696-2007-
dc.identifier.urihttp://hdl.handle.net/10261/23816-
dc.descriptionTesis del Departament de Química de la Universitat Autònoma de Barcelona (UAB).-- Fecha de defensa 2-2-2007.en_US
dc.description.abstract[EN] Amino acid lipid conjugates possess excellent surface properties, high biodegradability and low toxicity. Among them, arginine-based surfactants show a broad antimicrobial activity.en_US
dc.description.abstractThe mode of action of arginine-based surfactants was investigated. Thus, their interaction with membrane models (liposomes and phospholipid monolayers) and the effects caused on Staphylococcus aureus and Escherichia coli were studieden_US
dc.description.abstractThe antimicrobial efficacy of the arginine-based surfactants synthesised previously in our research group was improved. To this end, novel bis(phenylacetylarginine) derivatives were prepared chemoenzymatically.en_US
dc.description.abstractFinally and with the aim of preparing novel antimicrobial agents, we prepared a new family of amphiphilic compounds, N-alkylated derivatives of D-fagomine, using fructose-6-phosphaste aldolase (FSA) as biocatalyst.en_US
dc.description.abstract[ES] Los conjugados de lípidos y aminoácidos presentan excelentes propiedades tensioactivas, alta biodegradabilidad y baja toxicidad. De entre ellos, los derivados de arginina poseen un amplio espectro de actividad antimicrobiana.en_US
dc.description.abstractCon el objetivo de elucidar el modo de acción de los tensioactivos derivados de arginina, se ha investigado su interacción con modelos de membrana (liposomas y monocapas de fosfolípidos) y se ha evaluado los efectos que causan en Staphylococcus aureus y Escherichia coli.en_US
dc.description.abstractLa eficacia antimicrobiana de los tensioactivos derivados de L-arginina previamente sintetizados en nuestro grupo de investigación se ha mejorado. Para ello, se ha preparado quimo-enzimáticamente una nueva familia de derivados de L-arginina, bis(fenilacetilargininas).en_US
dc.description.abstractFinalmente y con el propósito de preparar nuevos posibles agentes antimicrobianos, se ha sintetizado una familia de compuestos anfifílicos, derivados alquilados de D-fagomina, empleando fructosa-6-fosfato aldolasa (FSA) como biocatalizador.en_US
dc.format.extent4394283 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherUniversidad Autónoma de Barcelonaen_US
dc.rightsopenAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectArginine-based surfactantsen_US
dc.subjectFructose 6-phosphate aldolaseen_US
dc.titleStudies on antimicrobial activity of arginine-based surfactants and chemo- enzymatic synthesis of novel amphiphiles based on L-arginine and D-fagomineen_US
dc.typetesis doctoralen_US
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://www.tdx.cat/TDX-0412107-125438en_US
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