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Title: | Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes |
Authors: | Martín-Sanz, Paloma ; Cascales, Maria; Boscá, Lisardo CSIC ORCID CVN | Issue Date: | 1-Feb-1989 | Publisher: | Portland Press Biochemical Society |
Citation: | Biochemical Journal 257(3): 795-799 (1989) | Abstract: | The sensitivity of 6-phosphofructo-2-kinase to glucagon and cyclic AMP was studied during the perinatal period. In liver homogenates from foetal and neonatal rats, incubation with cyclic AMP produced inactivation of 6-phosphofructo-2-kinase 3 h after birth. The maximal effect was obtained 12 h after birth. In primary cultures of hepatocytes from 22-day-old foetuses, glucogon induced an inhibition of 6-phosphofructo-2-kinase that required 45 min to reach the half-maximal effect. Cycloheximide prevented the glucagon-induced changes in this activity from cultured foetal hepatocytes. These results suggest that the adult form of 6-phosphofructo-2-kinase is rapidly induced after birth, probably by the hormonal changes that occur in this period. | Description: | 5 pages, 3 figures, 1 table. | Publisher version (URL): | http://www.biochemj.org/bj/257/bj2570795.htm | URI: | http://hdl.handle.net/10261/23781 | ISSN: | 0264-6021 |
Appears in Collections: | (IIBM) Artículos |
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