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Glucagon-induced changes in fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase in cultured rat foetal hepatocytes

AuthorsMartín-Sanz, Paloma ; Cascales, Maria; Boscá, Lisardo CSIC ORCID CVN
Issue Date1-Feb-1989
PublisherPortland Press
Biochemical Society
CitationBiochemical Journal 257(3): 795-799 (1989)
AbstractThe sensitivity of 6-phosphofructo-2-kinase to glucagon and cyclic AMP was studied during the perinatal period. In liver homogenates from foetal and neonatal rats, incubation with cyclic AMP produced inactivation of 6-phosphofructo-2-kinase 3 h after birth. The maximal effect was obtained 12 h after birth. In primary cultures of hepatocytes from 22-day-old foetuses, glucogon induced an inhibition of 6-phosphofructo-2-kinase that required 45 min to reach the half-maximal effect. Cycloheximide prevented the glucagon-induced changes in this activity from cultured foetal hepatocytes. These results suggest that the adult form of 6-phosphofructo-2-kinase is rapidly induced after birth, probably by the hormonal changes that occur in this period.
Description5 pages, 3 figures, 1 table.
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Appears in Collections:(IIBM) Artículos

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