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Title

Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase

AuthorsObregón, María Jesús
Issue Date15-Apr-1989
PublisherPortland Press
Biochemical Society
CitationBiochemical Journal 259(2): 341-346 (1989)
AbstractIn order to investigate the postnatal recruitment process, gene expression in the brown adipose tissue of rat pups was followed during the first 20 h of life. In normal pups, the level of mRNA coding for the uncoupling protein thermogenin increased markedly but gradually within the first 24 h. Lipoprotein lipase and actin mRNA levels were relatively low and remained constant. In pups exposed to thermoneutral temperature (35 degrees C) for the first 12 h after birth, no increase in thermogenin mRNA or lipoprotein lipase mRNA was observed, whereas in pups exposed to 28 degrees C a clear increase in both thermogenin and lipoprotein lipase mRNA levels was found. Actin mRNA levels were not affected by the environmental temperature under these circumstances. It was concluded that the postnatal recruitment in brown adipose tissue is a consequence of the cold stress experienced by the newborn pups. Thus, postnatal recruitment is not ontogenically predetermined.
Description6 pages, 2 figures, 1 table.-- et al.
Publisher version (URL)http://www.biochemj.org/bj/259/0341/bj2590341_browse.htm
URIhttp://hdl.handle.net/10261/23779
ISSN0264-6021
Appears in Collections:(IIBM) Artículos




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