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Título: | Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics |
Autor: | Yaron, Jordan R.; Liqiang, zhang; Guo, Qiuyun; Burgin, Michelle; Schutz, Lauren N.; Awo, Enkidia; Wise, Lyn; Krause, Kurt L.; Ildefonso, Cristhian J.; Kwiecien, Jacek M.; Juby, Michael; Rahman, Masmudur M.; Chen, Hao; Moye, Richard W.; Alcamí, Antonio CSIC ORCID; McFadden, Grant; Lucas, Alexandra R. | Palabras clave: | Virus Immune modulation Protein Serpin chemokine binding protein Chemokine Growth factor Cytokine Interleukin Therapeutic Biologic |
Fecha de publicación: | 31-mar-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Journal of Clinical Medicine 9 (2020) | Resumen: | Viruses are widely used as a platform for the production of therapeutics. Vaccines containing live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key examples of clinically-approved therapeutic uses for viruses. Despite this, the use of virus-derived proteins as natural sources for immune modulators remains in the early stages of development. Viruses have evolved complex, highly e ective approaches for immune evasion. Originally developed for protection against host immune responses, viral immune-modulating proteins are extraordinarily potent, often functioning at picomolar concentrations. These complex viral intracellular parasites have “performed the R&D”, developing highly e ective immune evasive strategies over millions of years. These proteins provide a new and natural source for immune-modulating therapeutics, similar in many ways to penicillin being developed from mold or streptokinase from bacteria. Virus-derived serine proteinase inhibitors (serpins), chemokine modulating proteins, complement control, inflammasome inhibition, growth factors (e.g., viral vascular endothelial growth factor) and cytokine mimics (e.g., viral interleukin 10) and/or inhibitors (e.g., tumor necrosis factor) have now been identified that target central immunological response pathways. We review here current development of virus-derived immune-modulating biologics with effcacy demonstrated in pre-clinical or clinical studies, focusing on pox and herpesviruses-derived immune-modulating therapeutics | Versión del editor: | http://dx.doi.org/10.3390/jcm9040972 | URI: | http://hdl.handle.net/10261/235837 | DOI: | 10.3390/jcm9040972 | Identificadores: | doi: 10.3390/jcm9040972 issn: 2077-0383 |
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