English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/23176
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study

AuthorsAlmeida, Joao A. S.; Morán, María del Carmen; Infante, María Rosa ; Pais, Alberto A. C. C.
KeywordsArginine-based cationic surfactants
DPPC liposomes
Membrane organization
Issue Date24-Jun-2009
PublisherArkat USA
CitationARKIVOC : free online journal of organic chemistry 2010(5): 34-50 (2010)
AbstractThe effect of two arginine-based cationic surfactants, arginine N-lauroyl amide dihydrochloride and arginine O-lauroyl ester dihydrochloride, upon dipalmitoylphosphatidylcholine liposomes, is addressed in this work. Some aspects concerning the synthesis of these surfactants are also presented in some detail. Differential scanning calorimetry, as well as fluorescence anisotropy using several probes, is used to assess the relative effects on the lipid model membranes. In spite of the structural similarity among these molecules, which differ only by the group that connects the polar head to the tail, experimental results suggest differences in their behavior. Molecular dynamics simulation provides significant insight into the molecular mechanism that governs this interaction. A rationale is provided in terms of lipid-surfactant hydrogen bonding and the consequent positioning of the surfactant molecule within the bilayer.
Description17 pages, 10 figures, 2 tables.-- Issue title: "Issue in Honor of Prof. António M. d’A. Rocha Gonçalves".
Publisher version (URL)www.arkat-usa.org/get-file/29234
URIhttp://hdl.handle.net/10261/23176
ISSN1551-7004
E-ISSN1551-7012
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
Almeida_et_al.pdf423,91 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.