English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/23103
Title: Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
Authors: Balsa, A.; Cabezón, Arancha; Orozco, G.; Cobo, Tatiana; Miranda-Carus, Eugenia; López-Nevot, M. A.; Vicario, José Luis; Martín-Mola, Emilio; Martín, J.; Pascual-Salcedo, Dora
Issue Date: 6-Apr-2010
Publisher: BioMed Central
Citation: Arthritis Research and Therapy 12: R62 (2010)
Abstract: [Introduction] To investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF).
[Methods] We studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined.
[Results] We found an increased frequency of HLA DRB1 alleles with the shared epitope (SE) in ACPA-positive RA. Inversely, HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA, and a similar trend was found for HLA DR3. However these results could not be confirmed after stratification for the presence of the SE, probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found.
[Conclusions] HLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA.
Description: 25 pages, 2 figures, 5 tables.-- Provisional PDF.
Publisher version (URL): http://dx.doi.org/10.1186/ar2975
URI: http://hdl.handle.net/10261/23103
DOI: 10.1186/ar2975
ISSN: 1478-6354
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
ar2975.pdf177,48 kBAdobe PDFThumbnail
Show full item record

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.