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Título: | Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins |
Autor: | Alzahofi, Noura; Welz, Tobias; Robinson, Christopher L.; Page, Emma L.; Briggs, Deborah A.; Stainthorp, Amy K.; Reekes, James; Elbe, David A.; Straub, Felix; Kallemeijn, Wouter W.; Tate, Edward W.; Goff, Philip S.; Sviderskaya, Elena V.; Cantero, Marta; Montoliu, Lluís CSIC ORCID ; Nedelec, Francois; Miles, Amanda K.; Bailly, Maryse; Kerkhoff, Eugen; Hume, Alistair N. | Palabras clave: | Actin Cell biology Cytoskeleton |
Fecha de publicación: | 2020 | Editor: | Springer Nature | Citación: | Nature Communications 11: 3495 (2020) | Resumen: | Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organelle dispersion in opposition to microtubules. This suggests that in animals, as in yeast and plants, myosin/actin can drive long-range transport. Here, we show that the SPIRE-type actin nucleators (predominantly SPIRE1) are Rab27a effectors that co-operate with formin-1 to generate actin tracks required for myosin-Va-dependent transport in melanocytes. Thus, in addition to melanophilin/myosin-Va, Rab27a can recruit SPIREs to melanosomes, thereby integrating motor and track assembly activity at the organelle membrane. Based on this, we suggest a model in which organelles and force generators (motors and track assemblers) are linked, forming an organelle-based, cell-wide network that allows their collective activity to rapidly disperse the population of organelles long-distance throughout the cytoplasm. | Descripción: | © The Author(s) 2020. | Versión del editor: | http://dx.doi.org/10.1038/s41467-020-17212-6 | URI: | http://hdl.handle.net/10261/229694 | DOI: | 10.1038/s41467-020-17212-6 | E-ISSN: | 2041-1723 |
Aparece en las colecciones: | (CNB) Artículos |
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Rab27a_Alzahofi_PV_Art2020.pdf | 6,92 MB | Adobe PDF | Visualizar/Abrir |
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