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Title

Estrogenic Regulation of Glia and Neuroinflammation

AuthorsCrespo-Castrillo, Andrea; Arévalo, María Ángeles ; García-Segura, Luis M. ; Yanguas-Casás, Natalia
Keywordstheta
long-term potentiation
cofilin
RhoA
BDNF
spines
polymerization
Issue Date 2
PublisherOxford University Press (OUP)
CitationEstrogens and Memory: 96- 116 (2020)
AbstractEstrogens are rapid and potent facilitators of synaptic plasticity in the adult brain; however, the steps that link estrogens to factors that regulate synaptic strength remain unclear. The present chapter will first review the acute effects of 17β‎-estradiol on synaptic transmission and long-term potentiation (LTP). It will then describe a synaptic model used to study the substrates of LTP and provide evidence for the ability of estradiol to rapidly engage a selective actin signaling cascade associated with the consolidation of LTP. Finally, it will be shown that chronic reductions in estradiol levels disrupt LTP and actin dynamics but can be reversed by acute infusions of the hormone. It is concluded here that estradiol can promote learning-related plasticity by modifying the synaptic cytoskeleton.
Publisher version (URL)http://dx.doi.org/10.1093/oso/9780190645908.003.0008
URIhttp://hdl.handle.net/10261/229436
Identifiersdoi: 10.1093/oso/9780190645908.003.0008
Appears in Collections:(IC) Libros y partes de libros
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