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Título

From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities

AutorHernáez, Álvaro; Jaramillo Carmona, Sara M. ; García Borrego, Aránzazu CSIC ORCID ; Espejo-Calvo, Juan Antonio; Covas, María Isabel; Blanchart, Gemma; Torre, Rafael de la; Carrasco-Pancorbo, Alegría; Mesa, María Dolores; Fernández-Prior, África CSIC ORCID; Castañer, Olga; Fitó, Montserrat
Palabras claveOlive trees
Phenolic compound
Triterpenes
Bioactivity
Functional olive oil
3,4-dihydroxyphenylglycol
Hydroxytyrosol
Oleuropein
Oleocanthal
Fecha de publicación30-ene-2021
EditorMultidisciplinary Digital Publishing Institute
CitaciónAntioxidants 10 (2): 202 (2021)
ResumenOur aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0.05–0.5 μmol/L; Ts: 0.001–0.1 μmol/L) and nutraceutical doses (Ps: 1–10 μmol/L; Ts: 0.25–10 μmol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol (95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15 μmol/L; final nutraceutical concentration: 3 μmol/L) was the best in order to prepare functional products and nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among different olive components.
Descripción14 Páginas.-- 3 Tablas.-- 1 Esquema
Versión del editorhttp:dx.doi.org/10.3390/antiox10020202
URIhttp://hdl.handle.net/10261/229165
E-ISSN2076-3921
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