English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/228777
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Steroidogenic machinery in the adult rat colon

AuthorsDiviccaro, Silvia; Giatti, S.; Borgo, Francesca; Falvo, E.; Caruso, D.; García-Segura, Luis M. ; Melcangi, R. C.
KeywordsNeuroactive steroids
Sex steroids
Steroidogenic enzymes
Gut
Liquid
chromatography-tandem mass spectrometry
Issue Date 7
PublisherElsevier
CitationJournal of Steroid Biochemistry and Molecular Biology 203 (2020)
AbstractGastrointestinal function is known to be regulated by steroid molecules produced by the gonads, the adrenal glands and the gut microbiota. However, we have a limited knowledge on the functional significance of local steroid production by gastrointestinal tract tissue. On this basis, we have here evaluated, as a first methodological approach, the expression of steroidogenic molecules and the local levels of key steroids in the male rat colon. Our findings indicate that the colon tissue expresses molecules involved in the early steps of steroidogenesis and in the consecutive synthesis and metabolism of steroid hormones, such as progesterone, testosterone and 17β-estradiol. In addition, the levels of the steroid hormone precursor pregnenolone and the levels of active metabolites of progesterone and testosterone, such as dihydroprogesterone, tetrahydroprogesterone, dihydrotestosterone and 17β-estradiol, were higher in colon than in plasma. Higher levels of the androgen metabolite 3α-diol were detected in the colon in comparison with another non-classical steroidogenic tissue, such as the cerebral cortex. These findings suggest the existence of local steroid synthesis and metabolism in the colon, with the production of active steroid metabolites that may impact on the activity of the enteric nervous system and on the composition of the gut microbiota.
Publisher version (URL)http://dx.doi.org/10.1016/j.jsbmb.2020.105732
URIhttp://hdl.handle.net/10261/228777
Identifiersdoi: 10.1016/j.jsbmb.2020.105732
issn: 1879-1220
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.