Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/228170
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception |
Autor: | Sánchez-Blázquez, Pilar CSIC ORCID ; Cortés-Montero, Elsa CSIC ORCID; Rodríguez-Muñoz, María; Garzón-Niño, Javier | Palabras clave: | Sigma 2 receptor Sigma 1 receptor Knockout mice Mu opioid receptor Neuropathic pain Analgesia |
Fecha de publicación: | 11-nov-2020 | Editor: | BioMed Central | Citación: | Molecular Brain 13 (2020) | Resumen: | The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to investigate its potential role as a regulator of opioid analgesia and of pain hypersensitivity in σ2R knockout mice. In contrast to σ1R deficient mice, σ2R knockout mice developed mechanical allodynia following establishment of chronic constriction injury-induced neuropathic pain, which was alleviated by the σ1R antagonist S1RA. The analgesic effects of morphine, [D-Ala, N-MePhe, Gly-ol]-encephalin (DAMGO) and β-endorphin increased in σ1R mice and diminished in σ2R mice. The analgesic effect of morphine was increased in σ2R mice by treatment with S1RA. However, σ2R mice and wild-type mice exhibited comparable antinociceptive responses to the delta receptor agonist [D-Pen2,5]-encephalin (DPDPE), the cannabinoid type 1 receptor agonist WIN55,212-2 and the α2-adrenergic receptor agonist clonidine. Therefore, while σR1 inhibits and σ2R facilitates MOR-mediated analgesia these receptors exchange their roles when regulating neuropathic pain perception. Our study may help identify new pharmacological targets for diminishing pain perception and improving opioid detoxification therapies. | Versión del editor: | http://dx.doi.org/10.1186/s13041-020-00676-4 | URI: | http://hdl.handle.net/10261/228170 | DOI: | 10.1186/s13041-020-00676-4 | Identificadores: | doi: 10.1186/s13041-020-00676-4 issn: 1756-6606 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
The Sigma 2 receptor promotes.pdf | 1,55 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
122
checked on 24-abr-2024
Download(s)
84
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons