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Title

Neuronize v2: Bridging the Gap Between Existing Proprietary Tools to Optimize Neuroscientific Workflows

AuthorsVelasco, Iván; Toharia, P.; Benavides-Piccione, Ruth ; Fernaud-Espinosa, Isabel ; Brito, J.P.; Mata, S.; DeFelipe, Javier ; Pastor, L.; Bayona, S.
Keywordsneuron morphology
interoperability
neuronal tracing
spine meshes
data sharing
3D morphological reconstruction
pyramidal structure
Issue Date 6
PublisherFrontiers Research Foundation
CitationFrontiers in neuroanatomy 14 (2020)
AbstractKnowledge about neuron morphology is key to understanding brain structure and function. There are a variety of software tools that are used to segment and trace the neuron morphology. However, these tools usually utilize proprietary formats. This causes interoperability problems since the information extracted with one tool cannot be used in other tools. This article aims to improve neuronal reconstruction workflows by facilitating the interoperability between two of the most commonly used software tools—Neurolucida (NL) and Imaris (Filament Tracer). The new functionality has been included in an existing tool—Neuronize—giving rise to its second version. Neuronize v2 makes it possible to automatically use the data extracted with Imaris Filament Tracer to generate a tracing with dendritic spine information that can be read directly by NL. It also includes some other new features, such as the ability to unify and/or correct inaccurately-formed meshes (i.e., dendritic spines) and to calculate new metrics. This tool greatly facilitates the process of neuronal reconstruction, bridging the gap between existing proprietary tools to optimize neuroscientific workflows.
Publisher version (URL)http://dx.doi.org/10.3389/fnana.2020.585793
URIhttp://hdl.handle.net/10261/227614
Identifiersdoi: 10.3389/fnana.2020.585793
issn: 1662-5129
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