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Título

Evolution of cytokine production capacity in ancient and modern European populations

Otros títulosEvolution of cytokine production in Europeans
AutorDomínguez-Andrés, Jorge; Kuijpers, Yunus; Bakker, Olivier B.; Jaeger, Martin; Xu, Cheng-Jian; Meer, Jos W. M. van der; Jakobsson, Mattias; Bertranpetit, Jaume CSIC ORCID ; Joosten, Leo A. B.; Li, Yang; Netea, Mihai G.
Fecha de publicación17-ene-2021
EditorBioRxiv
CitaciónBioRxiv: 10.1101/2021.01.14.426690 (2021)
ResumenAs our ancestors migrated throughout the different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits influencing the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.
Versión del editorhttps://doi.org/10.1101/2021.01.14.426690
URIhttp://hdl.handle.net/10261/226933
DOI10.1101/2021.01.14.426690
Aparece en las colecciones: (PTI Salud Global) Colección Especial COVID-19
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