Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/225752
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Estévez-Sarmiento, Francisco | - |
dc.contributor.author | Saavedra, Ester | - |
dc.contributor.author | Ruiz-Estévez, Mercedes | - |
dc.contributor.author | León, Francisco | - |
dc.contributor.author | Quintana, José | - |
dc.contributor.author | Brouard, Ignacio | - |
dc.contributor.author | Estévez, Francisco | - |
dc.date.accessioned | 2020-12-28T14:30:13Z | - |
dc.date.available | 2020-12-28T14:30:13Z | - |
dc.date.issued | 2020-12-21 | - |
dc.identifier | doi: 10.3390/ijms21249767 | - |
dc.identifier.citation | International Journal of Molecular Sciences 21(24): 9767 (2020) | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10261/225752 | - |
dc.description | This article belongs to the Section Bioactives and Nutraceuticals. | - |
dc.description.abstract | Guaiane-type sesquiterpene lactones are naturally occurring compounds which have attracted attention due to their array of biological activities. In this study, chlorinated guaianolides <b>1</b>–<b>8</b>, isolated from plants of the genus <i>Centaurea</i>, were evaluated against the human leukemia cell lines HL-60, U-937, a specific U-937 cell line that overexpresses the anti-apoptotic Bcl-2 protein and the human melanoma cell line SK-MEL-1. This established the relevant structure-growth inhibition relationships. Chlorohyssopifolins A (<b>1</b>), C (<b>3</b>) and D (<b>4</b>) and linichlorin A (<b>6</b>) were the most potent compounds in terms of inducing growth inhibition in the four cell lines. IC<sub>50</sub> values were below 10 μM in all cases. Chlorohyssopifolins A (<b>1</b>) and D (<b>4</b>) and linichlorin A (<b>6</b>) were potent apoptotic inducers in human U-937 leukemia cells, as determined by fluorescent microscopy and flow cytometry, and their mechanism of action was associated with cytochrome <i>c</i> release, caspase activation and poly(ADP-ribose)polymerase cleavage. Overall this study shows that guaianolides induce cytotoxicity against human tumor cells and provides important insights into the cell death pathways that are involved. | - |
dc.description.sponsorship | This research was funded by FEDER and AGENCIA CANARIA DE INVESTIGACIÓN, INNOVACIÓN Y SOCIEDAD DE LA INFORMACIÓN (PROID2017010095 FEDER/ACIISI) and in part by the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund (PGC2018-094503-B-C21). | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094503-B-C21 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Apoptosis | - |
dc.subject | Cytotoxicity | - |
dc.subject | Caspases | - |
dc.subject | Poly(ADP-ribose) polymerase | - |
dc.subject | Sesquiterpene lactone | - |
dc.subject | Guaianolide | - |
dc.title | Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/ijms21249767 | - |
dc.relation.publisherversion | http://doi.org/10.3390/ijms21249767 | - |
dc.identifier.e-issn | 1422-0067 | - |
dc.date.updated | 2020-12-28T14:30:14Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Agencia Canaria de Investigación, Innovación y Sociedad de la Información | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007757 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.pmid | 33371413 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IPNA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
ijms-21-09767-v2.pdf | 3,45 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
5
checked on 01-abr-2024
SCOPUSTM
Citations
10
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
7
checked on 23-feb-2024
Page view(s)
108
checked on 23-abr-2024
Download(s)
166
checked on 23-abr-2024