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Use of [Cit312,314] filaggrin (306–324) analogue for the diagnosis of rheumatoid arthritis. Conformational study by circular dichroism and fourier transformed infrared spectroscopy

AuthorsPérez, Teresa; Gómez, Antoni; Sanmartí, Raimon; Viñas, Odette; Ercilla, Guadalupe; Haro Villar, Isabel
KeywordsCircular dichroism
Conformational study
Fourier transformed infrared spectroscopy
Rheumatoid arthritis
Synthetic peptides
Issue DateNov-2002
CitationLetters in Applied Microbiology 78(6): 1171-1179 (2002)
AbstractAntifilaggrin autoantibodies (AFA) have described to be the most specific markers of rheumatoid arthritis (RA) and epitopes containing citrulline within the sequence of filaggrin identified as major antigenic sites recognised by AFA. In this paper we confirm that citrulline is an essential constituent of filaggrin related antigenic determinants recognised by RA specific autoantibodies, thus having an important role for the development of filaggrin peptides based serological tests. Moreover, we describe our findings on the comparative conformational analysis of filaggrin (306–324) peptide sequence and an analogue in which two arginines were simultaneously substituted by citrulline carried out by Circular Dichroism (CD) and Fourier-Transform Infrared Spectroscopy (FTIR). Results might contribute to the understanding of the structural features that may be important to explain the enhanced binding characteristics of citrullinated peptides to the autoantibodies in rheumatoid arthritis.
Description10 pages, 6 figures, 5 tables.-- Available online Aug 1, 2006.
Publisher version (URL)http://dx.doi.org/10.1007/BF02447554
Appears in Collections:(IQAC) Artículos
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