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Open Access item Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

Authors:Palma, Giada de
Nadal, Inmaculada
Medina, Marcela Susana
Donat, Ester
Ribes-Koninckx, Carmen
Calabuig, Miguel
Sanz, Yolanda
Issue Date:24-Feb-2010
Publisher:BioMed Central
Citation:BMC Microbiology 10(63): (2010)
Abstract:[Background] Coeliac disease is a chronic intestinal inflammatory disorder caused by an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition in faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.
[Results] IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P<0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P<0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P<0.050) in both CD patients in comparison with healthy controls.
[Conclusions] In CD patients, reduced IgA-coating bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
Description:25 pages, 2 figures, 2 tables.-- Provisional PDF.
Publisher version (URL):http://dx.doi.org/10.1186/1471-2180-10-63
Appears in Collections:(IATA) Artículos

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