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|Título :||Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children|
|Autor :||Palma, Giada de, Nadal, Inmaculada, Medina, Marcela Susana, Donat, Ester, Ribes-Koninckx, Carmen, Calabuig, Miguel, Sanz, Yolanda|
|Fecha de publicación :||24-Feb-2010|
|Resumen:||[Background] Coeliac disease is a chronic intestinal inflammatory disorder caused by an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition in faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.|
[Results] IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P<0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P<0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P<0.050) in both CD patients in comparison with healthy controls.
[Conclusions] In CD patients, reduced IgA-coating bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
|Descripción :||25 pages, 2 figures, 2 tables.-- Provisional PDF.|
|Versión del editor:||http://dx.doi.org/10.1186/1471-2180-10-63|
|Citación :||BMC Microbiology 10(63): (2010)|
|Appears in Collections:||(IATA) Artículos|