Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/222162
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer |
Autor: | Zagórska, Anna; Través, Paqui G. CSIC; Jiménez-García, Lidia; Strickland, Jenna D.; Oh, Joanne; Tapia, Francisco J.; Mayoral, Rafael CSIC; Lemke, Greg | Fecha de publicación: | 2020 | Editor: | Life Science Alliance | Citación: | Life Science Alliance 3(8): e202000694 (2020) | Resumen: | Genome-wide association studies have implicated the TAM receptor tyrosine kinase (RTK) Mer in liver disease, yet our understanding of the role that Mer and its related RTKs Tyro3 and Axl play in liver homeostasis and the response to acute injury is limited. We find that Mer and Axl are most prominently expressed in hepatic Kupffer and endothelial cells and that as mice lacking these RTKs age, they develop profound liver disease characterized by apoptotic cell accumulation and immune activation. We further find that Mer is critical to the phagocytosis of apoptotic hepatocytes generated in settings of acute hepatic injury, and that Mer and Axl act in concert to inhibit cytokine production in these settings. In contrast, we find that Axl is uniquely important in mitigating liver damage during acetaminophen intoxication. Although Mer and Axl are protective in acute injury models, we find that Axl exacerbates fibrosis in a model of chronic injury. These divergent effects have important implications for the design and implementation of TAM-directed therapeutics that might target these RTKs in the liver. | Versión del editor: | https://doi.org/10.26508/lsa.202000694 | URI: | http://hdl.handle.net/10261/222162 | DOI: | 10.26508/lsa.202000694 | E-ISSN: | 2575-1077 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
differenmer.pdf | 6,05 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
14
checked on 02-abr-2024
SCOPUSTM
Citations
23
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
16
checked on 27-feb-2024
Page view(s)
153
checked on 19-abr-2024
Download(s)
160
checked on 19-abr-2024