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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/22145
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dc.contributor.authorDíez, Diego-
dc.contributor.authorGrijota Martínez, María del Carmen-
dc.contributor.authorMorreale de Escobar, Gabriella-
dc.contributor.authorBernal, Juan-
dc.contributor.authorMorte, Beatriz-
dc.date.accessioned2010-03-09T12:34:02Z-
dc.date.available2010-03-09T12:34:02Z-
dc.date.issued2008-05-08-
dc.identifier.citationEndocrinology 149(8): 3989-4000 (2008)en_US
dc.identifier.issn0013-7227-
dc.identifier.urihttp://hdl.handle.net/10261/22145-
dc.descriptionet al.-
dc.description.abstractThyroid hormones have profound effects on mood and behavior, but the molecular basis of thyroid hormone action in the adult brain is relatively unknown. In particular, few thyroid hormone-dependent genes have been identified in the adult brain despite extensive work carried out on the developing brain. In this work we performed global analysis of gene expression in the adult rat striatum in search for genomic changes taking place after administration of T3 to hypothyroid rats. The hormone was administered in two different schedules: 1) a single, large dose of 25 µg per 100 g body weight (SD) or 2) 1.5 µg per 100 g body weight once daily for 5 d (RD). Twenty-four hours after the single or last of multiple doses, gene expression in the striatum was analyzed using Codelink microarrays. SD caused up-regulation of 149 genes and down-regulation of 88 genes. RD caused up-regulation of 18 genes and down-regulation of one gene. The results were confirmed by hybridization to Affymetrix microarrays and by TaqMan PCR. Among the genes identified are genes involved in circadian regulation and the regulation of signaling pathways in the striatum. These results suggest that thyroid hormone is involved in regulation of striatal physiology at multiple control points. In addition, they may explain the beneficial effects of large doses of thyroid hormone in bipolar disorders.en_US
dc.format.extent704023 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherEndocrine Societyen_US
dc.rightsopenAccessen_US
dc.subjectCentral-nervous-systemen_US
dc.subjectNeuronal expressionen_US
dc.subjectParkinsons-diseaseen_US
dc.subjectNuclear occupancyen_US
dc.subjectResponsive genesen_US
dc.subjectBinding proteinen_US
dc.titleThyroid hormone action in the adult brain: Gene expression profiling of the effects of single and multiple doses of triiodo-L-thyronine in the rat striatumen_US
dc.typeartículoen_US
dc.identifier.doi10.1210/en.2008-035-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1210/en.2008-0350en_US
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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