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Best Practices for Human Milk Collection for COVID-19 Research

Other TitlesCollecting Human Milk for COVID-19 Research
AuthorsMcGuire, Michelle K.; Seppo, Antti; Goga, Ameena; Buonsenso, Danilo; Collado, María Carmen ; Donovan, Sharon M.; Muller, Janis A.; Ofman, Gaston; Monroy-Valle, Michele; O'Connor, Deborah L.; Pace, Ryan M.; Van de Perre, Philippe
KeywordsHuman milk
Vertical transmission
Issue Date2-Oct-2020
PublisherResearch Square
AbstractIn addition to providing life-giving nutrients and other substances to the breastfed infant, human milk can also represent a vehicle of pathogen transfer. As such, when an infectious disease outbreak, epidemic, or pandemic occurs – particularly when it is associated with a novel pathogen – the question will naturally arise as to whether the pathogen can be transmitted via breastfeeding. Until high-quality data are generated to answer this question, abandonment of breastfeeding due to uncertainty can result. The COVID-19 pandemic, which was in full swing at the time this document was written, is an excellent example of this scenario. During these times of uncertainty, it is critical for investigators conducting research to assess the possible transmission of pathogens via milk, whether by transfer through the mammary gland or contamination from respiratory droplets, skin, breast pumps, and milk containers, and/or close contact between mother and infant. To promote the most rigorous science, it is critical to outline optimal methods for milk collection, handling, storage, and analysis in these situations, and investigators should openly share their methods in published materials. Otherwise, the risks of inconsistent test results from pre-analytical and analytical variation, false positives, and false negatives are unacceptably high and the ability to provide public health guidance poor. Here we provide “best practices” for collecting human milk samples for COVID-19 research with the intention that this will also be a useful guide for future pandemics.
Publisher version (URL)https://doi.org/10.21203/rs.3.rs-84403/v1
Appears in Collections:(IATA) Artículos
(VICYT) Colección Especial COVID-19
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