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Título: | Characterization of Fetal Brain Damage in Early Abortions of Ovine Toxoplasmosis |
Autor: | Gutiérrez-Expósito, Daniel CSIC ORCID ; Arteche-Villasol, Noive CSIC ORCID ; Vallejo García, Raquel CSIC ORCID; Ferreras, Mª del Carmen CSIC ORCID ; Ferre, Ignacio; Sánchez Sánchez, R.; Ortega Mora, Luis M.; Pérez Pérez, Valentín CSIC ORCID ; Benavides, Julio CSIC ORCID | Palabras clave: | bAPP Brain Early abortions Immunohistochemistry Leukomalacia Necrosis Sheep Toxoplasmosis |
Fecha de publicación: | 2020 | Editor: | Sage Publications | Citación: | Veterinary Pathology 57(4): 535-544 (2020) | Resumen: | There is an unacknowledged clinical presentation of ovine toxoplasmosis characterized by early abortions and lesions of fetal leukoencephalomalacia. To investigate the pathogenesis of this condition, the extent and distribution of leukomalacia and the variations in the cell populations associated with it were characterized in 32 fetal brains from 2 previously published experimental studies of Toxoplasma gondii infection in pregnant sheep. Immunohistochemical labeling of βAPP allowed for the detection of leukomalacia in 100/110 (91%) studied samples. There was no clear influence of the challenge dose or the area of the brain (frontal lobe, corpus callosum, midbrain, and cerebellum). In tissues with leukomalacia, there was loss of oligodendrocytes and increased number of astrocytes and microglia both in the areas of necrosis but also in the surrounding area. These findings were similar to those described in ovine experimental models (inflammation syndrome and hypoxic models) of periventricular leukomalacia in humans. Thus, a fetal inflammatory syndrome may be involved in the pathogenesis of early abortion in ovine toxoplasmosis. However, further studies are needed to determine the pathogenesis of this clinical presentation because placental thrombosis and resulting hypoxia could also be responsible for the leukomalacia. | Descripción: | 10 páginas, 2 tablas, 9 figuras. | Versión del editor: | http://dx.doi.org/10.1177/0300985820921539 | URI: | http://hdl.handle.net/10261/220549 | DOI: | 10.1177/0300985820921539 | ISSN: | 1544-2217 |
Aparece en las colecciones: | (IGM) Artículos |
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Gutierrez Exposito et al 2020 postprint.pdf | Artículo principal post print | 953,31 kB | Adobe PDF | Visualizar/Abrir |
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