Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/220330
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems |
Autor: | Pinazo Gassol, Aurora CSIC ORCID; Pons Pons, Ramón CSIC ORCID; Marqués, Ana María; Farfán, Maribel; da Silva, Anderson Ramos CSIC; Pérez, Lourdes CSIC ORCID | Palabras clave: | Catanionic vesicles Amino acids Biocompatible surfactants Antimicrobial activity Antibiofilm activity Hemolysis Bacterial selectivity |
Fecha de publicación: | 2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Pharmaceutics 12(9): 857 (2020) | Resumen: | Their stability and low cost make catanionic vesicles suitable for application as drug delivery systems. In this work we prepared catanionic vesicles using biocompatible surfactants: two cationic arginine-based surfactants (the monocatenary Nα-lauroyl-arginine methyl ester—LAM and the gemini Nα,Nϖ-bis(Nα-lauroylarginine) α, ϖ-propylendiamide—C3(CA)2) and three anionic amphiphiles (the single chain sodium dodecanoate, sodium myristate, and the double chain 8-SH). The critical aggregation concentration, colloidal stability, size, and charge density of these systems were comprehensively studied for the first time. These catanionic vesicles, which form spontaneously after mixing two aqueous solutions of oppositely charged surfactants, exhibited a monodisperse population of medium-size aggregates and good stability. The antimicrobial and hemolytic activity of the vesicles can be modulated by changing the cationic/anionic surfactant ratio. Vesicles with a positive charge efficiently killed Gram-negative and Gram-positive bacteria as well as yeasts; the antibacterial activity declined with the decrease of the cationic charge density. The catanionic systems also effectively eradicated MRSA (Methicillin-resistant Staphylococcus Aureus) and Pseudomonas aeruginosa biofilms. Interestingly, the incorporation of cholesterol in the catanionic mixtures improved the stability of these colloidal systems and considerably reduced their cytotoxicity without affecting their antimicrobial activity. Additionally, these catanionic vesicles showed good DNA affinity. Their antimicrobial efficiency and low hemolytic activity render these catanionic vesicles very promising candidates for biomedical applications. | Descripción: | © 2020 by the authors. | Versión del editor: | https://doi.org/10.3390/pharmaceutics12090857 | URI: | http://hdl.handle.net/10261/220330 | DOI: | 10.3390/pharmaceutics12090857 | E-ISSN: | 1999-4923 |
Aparece en las colecciones: | (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Biocompatible_Pinazo_Art2020.pdf | 4,83 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 28-mar-2024
SCOPUSTM
Citations
19
checked on 27-mar-2024
WEB OF SCIENCETM
Citations
19
checked on 26-feb-2024
Page view(s)
131
checked on 28-mar-2024
Download(s)
151
checked on 28-mar-2024