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Open Access item The “Gene” Experiment in the Spanish Soyuz Mission to the International Space Station. Effects of cold transportation

Authors:Herranz, Raúl
Laván, David A.
Benguria, Alberto
Duque, Pedro
Zaballos, Ángel
Medina, F. Javier
Van Loon, Jack JWA
Marco, Roberto
Gasset, Gilbert
Leandro, L. J.
Keywords:Drosophila, Microgravity
Issue Date:2007
Citation:Microgravity Science and Technology
Series/Report no.:19
Abstract:If exploration of outer space is going to be a major human enterprise in the future, it is important to establish the nature of the biological response to the space environment. In one of the recent Soyuz missions to serve the ISS, the Spanish Soyuz Mission in October 2003, we sent a group of Drosophila pupae that underwent almost complete development there. Microarray analyses of the RNAs extracted from flies fixed in the ISS revealed that a relatively large set of genes (15% of the total number assayed) suffered a significant expression change in these conditions. Furthermore, the samples had to be transported to the launch site and it was necessary to slow down their development by exposing them to a lower temperature, fully compatible with pupal development. Such a pre-exposure had an effect by itself on the pattern of gene expression observed after pupal development at normal temperature, but the two environmental factors seemed to act synergistically. These findings indicate the importance of maintaining a vigorous scientific program in the ISS to understand the consequences of the modified environment in outer space on living organisms.
Description:Manuscript version. Final Article available on the publisher site. http://www.springerlink.com/content/k5w4j8747211p13h/?p=1823d8063e69447cbbb58584de4e2425&pi=3
Publisher version (URL):10.1007/BF02919481
Appears in Collections:(CIB) Artículos

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