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Título: | CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity |
Autor: | Bueno, Clara; Velasco-Hernández, Talia CSIC ORCID; Gutiérrez-Agüera, Francisco; Zanetti, Samanta Romina; Baroni, Matteo L.; Sánchez-Martínez, Diego; Molina, Oscar; Closa, Adria; Agraz-Doblas, Antonio; Marín, Pedro; Eyras, Eduardo; Varela, Ignacio CSIC ORCID; Menéndez, Pablo | Palabras clave: | Acute lymphocytic leukaemia Immunotherapy |
Fecha de publicación: | 2019 | Editor: | Springer Nature | Citación: | Leukemia 33: 2090-2125 (2019) | Resumen: | Chimeric antigen receptors (CARs) have undoubtedly revolutionized immunotherapy, especially in the B-cell acute lymphoblastic leukemia (ALL) arena where over 80% of complete remissions are observed in refractory/relapsed (R/R) B-cell ALL patients treated with CD19-directed CAR T-cells (CARTs) [1]. However, despite holding an unprecedented promise, several issues still have to be resolved before CARTs can be expanded to novel targets and/or malignancies or even provided as first-line treatment in Bcell ALL [2]. For instance, toxicities such as cytokine release syndrome and immune escape mechanisms including loss of the antigen under CART-mediated pressure remain major concerns, urging further research on the mechanisms underlying CARTs cytotoxicity. | Descripción: | © The Author(s) 2019. | Versión del editor: | https://doi.org/10.1038/s41375-019-0418-8 | URI: | http://hdl.handle.net/10261/220030 | DOI: | 10.1038/s41375-019-0418-8 | ISSN: | 0887-6924 | E-ISSN: | 1476-5551 |
Aparece en las colecciones: | (IBBTEC) Artículos |
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CD133-directed_Bueno_Art2019.pdf | CD133-directed_Bueno_Art2019 | 800,38 kB | Adobe PDF | Visualizar/Abrir |
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