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Título: | A retino-retinal projection guided by Unc5c emerged in species with retinal waves |
Autor: | Murcia-Belmonte, Verónica CSIC ORCID; Vegar, Celia CSIC; Negueruela, Santiago CSIC ORCID; Juan Romero, Camino de CSIC ORCID; Valiño, Arturo José CSIC ; Sala, Salvador CSIC ORCID; Kania, Artur; Borrell, Víctor CSIC ORCID; Martínez, Luis M. CSIC ORCID ; Erskine, Lynda; Herrera, Eloisa CSIC ORCID | Fecha de publicación: | 2019 | Citación: | European Developmental Biology Congress (2019) | Resumen: | The existence of axons extending from one retina to the other has been reported during perinatal development in different vertebrates. However, it has been thought that these axons are either a labelling artefact or misprojections. Here, we unequivocally show that a small subset of retinal ganglion cells (RGCs) project to the opposite retina and that the guidance receptor Unc5c, expressed in the retinal region where the R-R neurons are located, is necessary and sufficient to guide axons to the opposite retina. In addition, Netrin1, an Unc5c ligand, is expressed in the ventral diencephalon in a pattern that is consistent with impeding the growth of Unc5c retinal axons into the brain. We have also generated a mathematical model to explore the formation of retinotopic maps in the presence and absence of a functional connection between both eyes. This model predicts that an R-R connection is required for the bilateral coordination of axonal refinement in species where refinement depends upon spontaneous retinal waves. Consistent with this idea, the retinal expression of Unc5c correlates with the existence and size of a R-R projection in different species and with the extent of axonal refinement in visual targets. These findings demonstrate that active guidance drives the formation of the R-R projection and suggest an important role for these projections in visual mapping to ensure congruent bilateral refinement. | Descripción: | Resumen del póster presentado al European Developmental Biology Congress (EDBC), celebrado en Alicante del 23 al 26 de octubre de 2019. También presentado al 3rd AXON-meeting, celebrado en Alicante (España) del 11 al 13 de septiembre de 2019. |
URI: | http://hdl.handle.net/10261/218065 |
Aparece en las colecciones: | (IN) Comunicaciones congresos |
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